Research Overview
Michael Weinfeld is a leader in the DNA damage and repair field, specializing in Polynucleotide Kinase/Phosphatase (PNKP) enzyme research and therapeutic development for cancer treatment. His work focuses on understanding DNA repair mechanisms and developing strategies to exploit repair deficiencies in cancer cells.
Research Focus
DNA Repair Enzymes
Investigation of key DNA repair enzymes, particularly PNKP, and their roles in maintaining genome stability and their potential as therapeutic targets.
Cancer Therapeutics
Development of novel therapeutic strategies that target DNA repair pathways in cancer cells, including combination approaches and personalized medicine.
Environmental Carcinogenesis
Study of how environmental factors cause DNA damage and contribute to cancer development, with focus on repair pathway responses.
Biomarker Development
Identification and validation of biomarkers related to DNA repair capacity for cancer prognosis and treatment selection.